There is a steady rise in the number of obese individuals who exhibit more than one chronic disease, making treatment and disease management more difficult. Obesity causes constant inflammation (metabolic inflammation ) — fat tissues secrete hormone-like substances called adipokines; increase of abdominal fat disrupts the normal signaling of these adipokines, resulting in inflammation that causes insulin resistance, thus hastening the development of type 2 diabetes, cardiovascular disease, chronic diseases of the liver, pancreas, gallbladder, kidneys, as well as some cancers.
